Medchemcomm

Recent Papers/Articles

On the enthalpic preference of fragment binding

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A homology modelling-driven study leading to the discovery of the first mouse trace amine-associated receptor 5 (TAAR5) antagonists

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eCF309: a potent, selective and cell-permeable mTOR inhibitor

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Amyloid [small beta] derived switch-peptides as a tool for investigation of early events of aggregation: a combined experimental and theoretical approach

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Synthesis and biological evaluation of D-gluconhydroximo-1,5-lactam and its oxime-substituted derivatives as pharmacological chaperones for the treatment of Gaucher disease

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Mechanisms of resistance to membrane-disrupting antibiotics in Gram-positive and Gram-negative bacteria

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Rubrolide analogues and their derived lactams as potential anticancer agents

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Tetrahydro-pyrimido-indoles as selective LIMK inhibitors: synthesis, selectivity profiling and structure-activity studies

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Enhancement of aqueous stability and fluorescence brightness of indocyanine green using small calix[4]arene micelles for near-infrared fluorescence imaging

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Systematic design of analogs of active compounds covering more than 1000 targets

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Biological evaluation of quinoline derivatives as inhibitors of human dihydroorotate dehydrogenase

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1,3,4-Oxadiazole derivatives as potential antitumor agents: discovery, optimization and biological activity valuation

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Efficacy of a novel ferrocenyl diaryl butene citrate compound as a biocide for preventing healthcare-associated infections

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Discovery of a novel binding pocket for CYP 2C9 inhibitors: crystallography, pharmacophore modelling and inhibitor SAR